The Human gC1qR/p32 Gene, C1qBP

The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis.

gC1qR is an ubiquitously expressed cell protein that interacts with the globular heads of C1q (gC1q) and many other ligands. In this study, the 7.8-kilobase pair (kb) human gC1qR/p32 (C1qBP) gene was cloned and found to consist of 6 exons and 5 introns. Analysis of a 1.3-kb DNA fragment at the 5'-flanking region of this gene revealed the presence of multiple TATA, CCAAT, and Sp1 binding sites. ...

The Role of Bacterial Vectors in the Expression of Human IFN-y Gene

Detection of the “Tim” gene of sheep Giardia using “Tim” Gene primers of Giardia with human origin

Giardiasis is an important human parasitic disease. Giardia is a genus composed of binuclear flagellate protozoa. Giardia duodenalis is a parasitic species for a wide range of vertebrates, including humans. Heterogeneity in G. duodenalis has been shown by serological, biochemical, and molecular analysis. In the present study, the possible genetic similarity between Giardia in sheep and humansan...

C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion1

Early studies suggested that the androgen receptor (AR) might play important roles to promote the renal cell carcinoma (RCC) progression; however, the detailed mechanisms remain unclear. Here we demonstrated the higher YBX1 expression with lower C1QBP expression in human RCC clinical tissues, and the intensity of C1QBP was negatively correlated with the YBX1 nuclear expression. Mechanism dissec...

AB093. C1QBP regulates YBX1 to suppress the androgen receptor (AR)-enhanced RCC cell invasion

Background: Early studies suggested that the androgen receptor (AR) might play important roles to promote the renal cell carcinoma (RCC) progression; however, the detailed mechanisms remain unclear. Methods: IHC was used to test C1QBP and YBX1 expression. RCC cell migration and invasion was analyzed in vitro and in vivo. CO-IP was used to test the interaction between C1QBP and YBX1. Results: We...